How AI and Blockchain Can Revolutionize Pharmaceutical Trials
It’s widely known by the pharmaceutical community that nearly nine out of ten drug candidates fail to win FDA approval, resulting in enormous drug development expenses every year. Less commonly understood is the underlying cause of these high failure rates, and what the pharmaceutical industry can do to overcome this challenge.
Currently, in an effort to lower such a high failure rate, especially in expensive late-phase clinical trials, pharmaceutical companies design early development processes to minimize financial risks. These smaller and much less expensive early clinical studies are intended to predict the outcomes of larger million dollar trials down the path to market.
However, it’s obvious that this approach isn’t working. Drug failure rates are approximately 90%, and for brand new drugs with no clinical data or drugs targeting complex conditions, there’s close to zero probability that it will be approved for market. For example, between 2002 and 2012, the failure rate for new drugs targeting Alzheimer’s disease was 99.6%, meaning only 0.4% made it to Phase III in the span of a decade.
But that’s not even the beginning. Once drugs make it to Phase III, there is approximately a 50% chance that the drug will achieve FDA approval. For more innovative, cutting-edge drugs, the success rate is closer to 25%.
In order to crack this Phase III puzzle, drug companies should consider leveraging artificial intelligence and blockchain technologies to execute clinical trials with more rigorous standards, more sophisticated designs, and higher likelihoods of success.
Read More: Interview With Dr. Spincer Koh, CEO, Gorilla Technology Group
P-Value Standards and Clinical Trial Success
P-values are a standard way that researchers measure the effectiveness of new drugs in Phase II trials in order to decide whether or not to advance the drug to Phase III. The concept of p-values is pretty simple: if a p-value is below 0.05, that means there is less than a 5% chance that the new drug’s effectiveness on patients is due to a random chance. In other words, that means there is an impressive 95% chance the drug is actually effective. A drug that achieves a p-value of 0.05 or less in Phase II trials will typically be advanced to Phase III.
Unfortunately, reality is more complicated and less predictable than statistical models might imply. It’s not actually the case that 95% of Phase III drugs achieve success; in fact, the success rate of Phase III drugs can be as low as 30%. The higher-than expected failure rates of late-stage trials are the result of many factors, including discrepancies between Phase II and Phase III testing populations and end-points.
Some experts, such as Professor David Colquhoun of University College London, have suggested that researchers can mitigate unexpected Phase III failures by adopting a more rigorous p-value standard of 0.001. In order to achieve such high standards of success, researchers should leverage new technologies like artificial intelligence and blockchain to enhance clinical trial design and execution.
Read More: Meet 20 Of The Most Powerful Women In The Tech World
The Promise of AI and Blockchain
AI and blockchain technologies can dramatically increase the success rates of late-stage clinical trials, saving both time and money and resulting in more effective research.
In a nutshell, blockchain is a secure distributed database shared by all parties in a distributed network where transaction data can be recorded and easily audited. Blockchain technology is already being developed and optimized in the pharmaceutical industry, from streamlining individual patient data to securing entire supply chains of products on a global scale. This technology is extremely efficient, flexible, and effective at everything from lowering costs to mitigating risks, and more.
AI is another technology that works hand in hand with blockchain. Together, these two technologies analyze data to better predict which drugs will be successful in clinical trials, preventing time and money from being wasted on developing drugs that ultimately aren’t successful candidates for later clinical trials. AI can also help investigators identify and track patients throughout multiple studies and provide better recruiting strategies to optimize the parameters of the trials, making p-values as low as 0.0001 a realistic goal.
One of the biggest benefits of combining blockchain and AI technologies is additional security, which in turn increases the number of patients who are willing to participate in studies, as they are reassured by the secure database that stores sensitive information about their medical conditions.
Another huge incentive for using blockchain and AI with clinical trials is its decentralized properties, enabling researchers to pull data from patients all around the country, including other studies, thereby solving the common problem of shortage of trial participants. All of these benefits make blockchain and AI technologies well worth integrating into the clinical trial industry, and there’s no better time to do so than now.
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比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。Telegram中文版
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。纸飞机中文
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。纸飞机中文
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
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The post provoked a lot of thought and taught me something new. Thank you for such engaging content.
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
The Writing is a treasure trove of knowledge, like finding an untouched library book. A rare gem!
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
The insights add so much value, like an unexpected compliment that brightens one’s day. Thanks for sharing.
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。Telegram中文版
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。Telegram官网
The Writing is a constant source of inspiration and knowledge. Thank you!
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Brilliant writing! You’ve captured the essence perfectly, much like a photographer captures a stunning landscape.
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
The insights light up my intellect like fireworks. Thanks for the show!
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Handling topics with grace and authority, like a professor, but without the monotone lectures.
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。纸飞机中文版
Your ideas and insights are unique and thought-provoking I appreciate how you challenge your readers to see things from a different perspective
The balance and fairness in The writing make The posts a must-read for me. Great job!
The Writing has become a go-to resource for me. The effort you put into The posts is truly appreciated.
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The insights dazzled me more than a candlelit dinner. Thanks for lighting up my intellect.
The thoughtful analysis has really made me think. Thanks for the great read!
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Visit the official Telegram website, choose the appropriate operating system such as Windows, macOS, Android, iOS, etc., and download the application. Enjoy seamless communication across devices with Telegram’s secure and fast messaging features, including text, voice calls, and file sharing, all backed by end-to-end encryption for enhanced privacy.飛機中文版
比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
The creativity and intelligence shine through, blinding almost, but I’ll keep my sunglasses handy.
The depth of The research is impressive, almost as much as the way you make hard to understand topics captivating.
The take on hard to understand topics is like a smooth ride in a luxury car—comfortable, yet exhilarating.
This is the most thorough piece I’ve read on the topic. The dedication to research is admirable.
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派官网(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。飛機中文版
The unique perspective on this subject was enlightening. It’s refreshing to see someone so passionate about their topic.
This blog has opened my eyes to new ideas and perspectives that I may not have considered before Thank you for broadening my horizons
The work is truly inspirational. I appreciate the depth you bring to The topics.
I appreciate how you’ve explained things so clearly. It really helped me understand the topic better.
The attention to detail is remarkable, like a detective at a crime scene, but for words.
比特派(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
The depth of The research really stands out. It’s clear you’ve put a lot of thought into this.
Always excited for The posts, because who else is going to make me feel this inadequately informed?
This post is packed with useful insights. Thanks for sharing The knowledge!
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Always excited for The posts, because who else is going to make me feel this inadequately informed?
Making hard to understand topics accessible is a talent. It’s like you’re the translator of my heart’s unspoken questions.
tg中文访问 Telegram网站,选择适合你的操作系统(Windows、macOS、Android、iOS 等),快速下载并安装 Telegram 应用。无论是桌面版还是移动版,Telegram 都为各平台提供完美适配,保障安全沟通与隐私保护。
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Visit the official Telegram website, choose the appropriate operating system such as Windows, macOS, Android, iOS, etc., and download the application. Enjoy seamless communication across devices with Telegram’s secure and fast messaging features, including text, voice calls, and file sharing, all backed by end-to-end encryption for enhanced privacy.Telegram中文版
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。纸飞机中文
前往 Telegram 官方网站,选择适合的操作系统(如 Windows、macOS、Android、iOS 等),并下载应用程序。纸飞机中文版
比特派下载(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
比特派钱包(Bitpie)是一款全球领先的多链数字钱包,专为支持多种区块链资产而设计,如比特币(BTC)、以太坊(ETH)、波场(TRX)、泰达币(USDT)等主流加密货币。通过使用比特派,用户不仅能够轻松便捷地管理和转移数字资产,还可以享受去中心化应用(DApp)等多种区块链服务
Shedding light on this subject like you’re the only star in my night sky. The brilliance is refreshing.
The passion is infectious, or maybe that’s just my enthusiasm trying to match Thes. Inspiring, nonetheless!
Delightful read. The passion is visible, or at least, very well faked.
Unique perspective? Check. Making me rethink my life choices? Double-check.
Visit the official Telegram website, choose the appropriate operating system such as Windows, macOS, Android, iOS, etc., and download the application. Enjoy seamless communication across devices with Telegram’s secure and fast messaging features, including text, voice calls, and file sharing, all backed by end-to-end encryption for enhanced privacy.Telegram官网
Most comprehensive article on this topic. I guess internet rabbit holes do pay off.