Charles River and Flagship’s Pioneering Medicines Enter Agreement Leveraging AI-Powered Logica with Aim of Creating Novel Therapies for Unmet Medical Needs

Logica, an offering from Charles River and Valo Health will be deployed by Pioneering Medicines across a portfolio of targets

Charles River Laboratories International, announced a multi-program agreement with Pioneering Medicines, a strategic initiative of Flagship Pioneering, that gives Pioneering Medicines access to Logica. Logica is an Artificial Intelligence (AI) powered drug solution that translates biological insights into optimized preclinical assets by leveraging Valo Health’s AI-powered Opal Computational Platform and Charles River’s leading preclinical expertise. Through the agreement, Pioneering Medicines will deploy Logica across a portfolio of targets with the aim of creating optimized small molecules that lead to novel therapies for unmet medical needs.

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“Logica’s unique platform has the capability to transform a drug target into a first-in-class development candidate in just over two years.”

“We are excited to work with the team at Pioneering Medicines to help accelerate the drug discovery process and deliver novel candidates to patients faster,” said Julie Frearson, PhD, Senior Vice President and Chief Scientific Officer, Charles River. “Logica’s unique platform has the capability to transform a drug target into a first-in-class development candidate in just over two years.”

“We’re entering this collaboration with both Charles River and Valo with a shared desire to increase efficiency in drug discovery,” said Paul Biondi, President, Pioneering Medicines and Executive Partner, Flagship Pioneering. “By utilizing Logica, a uniquely integrated AI platform, we’re hopeful that we can more quickly advance well-characterized molecules through the development process and create and deliver novel medicines for patients sooner.”

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The Strength of Logica, an Integrated AI Program

“With the combined power of Valo’s Opal Computational Platform and Charles River’s extensive drug discovery portfolio, Logica draws on a wide breadth of tools,” said Guido Lanza, Senior Vice President, and Logica General Manager, Valo Health. “We believe we have optimized drug discovery, coordinating laboratory infrastructure, expert drug hunters, and large-scale compute capabilities to eliminate whitespace and rapidly deliver results.”

In 2022, Charles River and Valo Health, Inc (“Valo”) launched Logica, leveraging Valo’s AI-powered Opal Computational Platform and Charles River’s leading preclinical expertise, providing clients with transformed drug discovery with a single integrated offering seamlessly translating targets to candidate nomination.

Logica utilizes industry-leading predictive models, chemical design and synthesis capabilities, DNA-encoded libraries, in silico high throughput screening from Valo’s Opal Computational Platform as well as Charles River’s leading capabilities in all aspects of discovery optimization including high throughput screening, medicinal chemistry, ADME, biology, pharmacology, and ultimately safety testing and IND submission, joining together for the first time to create a computation-powered, unified target-to-candidate offering. Logica is offered as a fully managed, risk-sharing model, with most of the client cost tied to success.

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