Phase Genomics Collaborates with Element Biosciences to Optimize Cytogenomics for Liquid and Solid Tumor Samples

The Element AVITI System rapidly delivers high-quality, cost-effective data to accelerate cytogenomic research on Phase Genomics’ OncoTerra Platform

Phase Genomics, a leading developer of cutting-edge genomic solutions, and Element Biosciences, the developer of an innovative DNA sequencing platform disrupting genomics, released new details of their first collaboration leveraging Phase Genomics’ proprietary OncoTerra cytogenomics platform and the Element AVITI System for next generation sequencing (NGS). Data generated from AVITI showed improvements in several key sequencing metrics, making it an ideal technology to pair with the proximity ligation-based OncoTerra cytogenomics platform for cancer research.

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“Our collaborative work with Phase Genomics underscores the versatility of the AVITI System in accurate genomic characterization of clinically relevant samples. Phase Genomics’ innovative approach to cytogenomics amplifies our joint impact in oncology research today, advancing the latest technology toward the clinic.”

“We’re extending the application of our core technologies into the oncology space, ensuring Phase Genomics’ next-generation cytogenomic tools deliver unparalleled precision, speed, and efficiency. We’re excited by what we’re seeing as a result of this recent work with Element,” said Ivan Liachko, PhD, co-founder and CEO of Phase Genomics. “Although OncoTerra is NGS platform agnostic, the high quality and accuracy of Element’s AVITI System make it a great option for data generation in next generation cytogenomics.”

The OncoTerra Platform paired with the AVITI System enables high-resolution cytogenomic analysis of solid-tumor samples, including archival formats, such as formalin-fixed, paraffin-embedded (FFPE) samples, that are largely unsuitable for conventional cytogenetic assays. Data generated on the Element AVITI System shows a lower level of duplicates and a higher proportion of high-quality read pairs. This increases the efficiency of OncoTerra library sequencing. OncoTerra delivers genome-wide cytogenomic insights from a wide array of sample types, including blood, fresh, and frozen tissues. Phase Genomics’ OncoTerra platform is the first offering to deliver the value of scalable cytogenomics for solid-tumor malignancies in the research setting.

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“Our work with Phase Genomics marks Element Biosciences’ first foray into the next-generation cytogenomics space for oncology,” said Shawn Levy, PhD, CSO and SVP of Applications at Element Biosciences. “Our collaborative work with Phase Genomics underscores the versatility of the AVITI System in accurate genomic characterization of clinically relevant samples. Phase Genomics’ innovative approach to cytogenomics amplifies our joint impact in oncology research today, advancing the latest technology toward the clinic.”

The OncoTerra platform leverages data from ubiquitous short-read sequencing technologies, like the Element AVITI NGS system, to identify novel and known genomic alterations. This information is key for oncology research applications. Phase Genomics and Element will share additional details and an application note at the upcoming AACR conference, April 14-19 (Phase Genomics booth #561, Element Biosciences booth #559). The application note demonstrates that with a single NGS-based assay, OncoTerra surpasses the breadth and depth of insights from current front-line cytogenetic diagnostics, including karyotyping, fluorescence in situ hybridization (FISH), and chromosomal microarrays.

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