Insilico Medicine Enters Research Collaboration With the University of Zurich to Apply Insilico’s Generative Artificial Intelligence Platform for the Discovery of Potential Therapeutics for Cystinosis

The MIKADO group, a translational team at the UZH focused on generating evidence-driven insights to understand and treat rare inherited kidney diseases, and Insilico Medicine, an end-to-end Artificial Intelligence (AI)-driven drug discovery company, announced a research and development collaboration designed to accelerate the discovery of transformative novel therapeutics for cystinosis. The duration of the initial research collaboration will be one year.

Specifically, the MIKADO group will leverage its multi-omics databank obtained from preclinical models and cystinosis-based cell models by using Insilico’s comprehensive novel target discovery AI platform PandaOmics to identify cellular and molecular pathways that drive life-threatening complications in cystinosis patients. The MIKADO group will analyse disease-relevant targetable pathways and utilize Insilico’s proprietary algorithms to generate libraries of small molecule compounds that are expected to be validated in preclinical models and cystinosis cell systems using disease-relevant screening technologies developed by the MIKADO group at the UZH.

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“I am thrilled by the collaboration between MIKADO and Insilico. With the power of artificial intelligence-driven, systems biology-based drug discovery, we intend to accelerate the analysis and discovery of drug targets, with the goal of bringing novel breakthrough medicines to cystinosis patients while decreasing costs and increasing probabilities of success,” said Olivier Devuyst, MD, Ph.D., head of MIKADO group at the UZH.

“Cystinosis is a commonly neglected disease with large unmet need. We are pleased to partner with MIKADO at the UZH combining the best of PandaOmics target discovery AI and human intelligence for the potential benefit of cystinosis patients worldwide,” said Alex Zhavoronkov Ph.D., CEO of Insilico Medicine.

Using innovative preclinical models and disease-relevant phenotype screening, we aim to validate novel drug targets for diseases which no cure has been found. Ultimately, we want to improve the quality of life for those affected by the disease and bring tangible hope to thousands of cystinosis patients around the world,” said Alessandro Luciani Ph.D., senior scientist and team leader at MIKADO.

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