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Roche Announces The Release Of Its Newest Artificial Intelligence Based Digital Pathology Algorithms To Aid Pathologists In Evaluation Of Breast Cancer Markers, Ki-67, ER And PR

Roche introduces three artificial intelligence (AI)-based, deep learning image analysis Research Use Only (RUO) algorithms developed for breast cancer, which is the second most common cancer in the world with an estimated 2.3 million new cases in 2020(1) and the most common cancer in women globally(1,2)
Manual methods for quantification of the breast cancer markers can be time consuming and have reported significant interobserver variability(2,3), which can impact decision making to determine patient therapy
Artificial intelligence (AI) advances and growing digitisation of pathology are a promising approach to meet the demand for more accurate detection, classification and prediction of patients with breast cancer(4,5)

Roche announced the research use only (RUO) launch of three new automated digital pathology algorithms, uPath Ki-67 (30-9), uPath ER (SP1) and uPath PR (1E2) image analysis for breast cancer, which are important biomarkers for breast cancer patients. Breast cancer is the second most common cancer in the world with an estimated 2.3 million new cases in 2020¹ and is the most common cancer in women globally. These new algorithms complete the Roche digital pathology breast panel of image analysis algorithms.

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uPath Ki-67 (30-9) image analysis, uPath ER (SP1) image analysis and uPath PR (1E2) image analysis for breast cancer use pathologist-trained deep learning algorithms to enable quick calculation of Ki-67, ER and PR tumour cell nuclei positivity. This includes a whole slide analysis workflow with automated pre-computing of the slide image prior to pathologist assessment, and a clear visual overlay highlighting tumour cells with and without nuclear staining. uPath Ki-67 (30-9) image analysis, uPath ER (SP1) image analysis and uPath PR (1E2) image analysis for breast cancer produce actionable assessments of scanned slide images that are objective and reproducible, aiding pathologists in quantification of these breast cancer markers.

Intended for use with Roche’s high medical value assays and slides stained on a BenchMark ULTRA instrument using ultraView DAB detection kit, the uPath Ki-67 (30-9) image analysis, uPath ER (SP1) image analysis and uPath PR (1E2) image analysis algorithms are ready-to-use and integrated within Roche’s uPath enterprise software and NAVIFY Digital Pathology, the cloud version of uPath. These algorithms are for Research Use Only. Not for use in diagnostic procedures.

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“Roche is committed to the expansion of digital pathology solutions to address unmet medical needs and breast cancer diagnostics is a key opportunity area. Innovations like image analysis algorithms have the potential to impact patient care by increasing the information available to pathologists and enhancing diagnostic confidence,” said Jill German, Head of Roche Diagnostics Pathology Customer Area.

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[To share your insights with us, please write to sghosh@martechseries.com]

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